Genomic Instability and Carcinogenesis: An Update
نویسندگان
چکیده
منابع مشابه
Genomic Instability and Carcinogenesis: An Update
Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development. In few instances, a "mutator mutation" has been clearly implicated in driving the accumulation of other ca...
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Studies have established that human cancers are principally genetic diseases, that is, they arise as consequence of the accumulation of a set of mutational events that enable a specific clone of tumor cells to develop. The precise number of genetic changes required for the events that remains unresolved in the pathogenesis of cancer range from few to several. This rev iew includes the nature of...
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Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile acids as a focus of this review since high levels of hydrophobic bile acids accompany a Western-style diet, and play a key role in colon carcinogenesis. We describe how bile acid-induced stresses cause cell death in susceptible cells, contribute to genomic instability in surviving cells, impose Darwinian sel...
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Colon cancer is the second most lethal cancer; approximately 600,000 people die of it annually in the world. Colon carcinogenesis generally follows a slow and stepwise process of accumulation of mutations under the influence of environmental and epigenetic factors. To adopt a personalized (tailored) cancer therapy approach and to improve current strategies for prevention, diagnosis, prognosis, ...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2008
ISSN: 1389-2029
DOI: 10.2174/138920208786847926